![[personal profile]](https://www.dreamwidth.org/img/silk/identity/user.png){kind=small}
grapefruit is weird
2020-10-11 13:05https://www.atlasobscura.com/articles/grapefruit-history-and-drug-interactions
Article via conuly.
* citrus genetics were weird and messy, if you didn't know that already.
* grapefruit is a feral hybrid discovered in Barbados, halfway around the world from Citrus Central.
* As you should learn if you don't know already, grapefruit has lots of drug interactions. Seems that's indirect: grapefruit disables stomach enzymes that normally break down most of an oral medication, so if you take the drug within 12 hours of grapefruit, you get much more drug than the prescription calls for. It can also disable some drug transporter proteins that bring things (like drugs) into cells, so in those cases you get less drug than expected.
* Tylenol is one of the drugs, though I'm not sure which class. I assume the second, from the lack of more strident recommendations not to mix them, because it's already too easy to OD on Tylenol.
* All the bitter pomelo derivatives have that effect, but you're "unlikely" to consume enough lime or sour orange for it to hurt, and I assume sweet orange doesn't have enough pomelo heritage, or didn't inherit the right genes.
Article via conuly.
* citrus genetics were weird and messy, if you didn't know that already.
* grapefruit is a feral hybrid discovered in Barbados, halfway around the world from Citrus Central.
* As you should learn if you don't know already, grapefruit has lots of drug interactions. Seems that's indirect: grapefruit disables stomach enzymes that normally break down most of an oral medication, so if you take the drug within 12 hours of grapefruit, you get much more drug than the prescription calls for. It can also disable some drug transporter proteins that bring things (like drugs) into cells, so in those cases you get less drug than expected.
* Tylenol is one of the drugs, though I'm not sure which class. I assume the second, from the lack of more strident recommendations not to mix them, because it's already too easy to OD on Tylenol.
* All the bitter pomelo derivatives have that effect, but you're "unlikely" to consume enough lime or sour orange for it to hurt, and I assume sweet orange doesn't have enough pomelo heritage, or didn't inherit the right genes.