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https://www.atlasobscura.com/articles/grapefruit-history-and-drug-interactions
Article via conuly.
* citrus genetics were weird and messy, if you didn't know that already.
* grapefruit is a feral hybrid discovered in Barbados, halfway around the world from Citrus Central.
* As you should learn if you don't know already, grapefruit has lots of drug interactions. Seems that's indirect: grapefruit disables stomach enzymes that normally break down most of an oral medication, so if you take the drug within 12 hours of grapefruit, you get much more drug than the prescription calls for. It can also disable some drug transporter proteins that bring things (like drugs) into cells, so in those cases you get less drug than expected.
* Tylenol is one of the drugs, though I'm not sure which class. I assume the second, from the lack of more strident recommendations not to mix them, because it's already too easy to OD on Tylenol.
* All the bitter pomelo derivatives have that effect, but you're "unlikely" to consume enough lime or sour orange for it to hurt, and I assume sweet orange doesn't have enough pomelo heritage, or didn't inherit the right genes.
Article via conuly.
* citrus genetics were weird and messy, if you didn't know that already.
* grapefruit is a feral hybrid discovered in Barbados, halfway around the world from Citrus Central.
* As you should learn if you don't know already, grapefruit has lots of drug interactions. Seems that's indirect: grapefruit disables stomach enzymes that normally break down most of an oral medication, so if you take the drug within 12 hours of grapefruit, you get much more drug than the prescription calls for. It can also disable some drug transporter proteins that bring things (like drugs) into cells, so in those cases you get less drug than expected.
* Tylenol is one of the drugs, though I'm not sure which class. I assume the second, from the lack of more strident recommendations not to mix them, because it's already too easy to OD on Tylenol.
* All the bitter pomelo derivatives have that effect, but you're "unlikely" to consume enough lime or sour orange for it to hurt, and I assume sweet orange doesn't have enough pomelo heritage, or didn't inherit the right genes.
no subject
Date: 2020-10-11 20:35 (UTC)From:1: "oh my god, people didn't know grapefruit was dangerous until 1989? what *other* dangers don't we know about?"
2: "American prescription bottles don't have no-grapefruit-allowed stickers?? god*dammit* America"
2: "hang on, haven't people been pretty worried about disruptions in the medication supply chain this year? can we stretch out scarce drugs by cutting the dose and then mixing them with grapefruit juice to potentiate them back up to normal?"
no subject
Date: 2020-10-11 20:37 (UTC)From:no subject
Date: 2020-10-11 20:51 (UTC)From:Maybe start by studying drugs that are *always* hard to get one's hands on. (...wait, that sounds like a euphemism for black-market drugs. I was actually thinking of highly expensive prescriptions.)
(Though even if we work out the dosages correctly, there's still the matter of "presumably those stomach enzymes were there for a *reason*"...)
no subject
Date: 2020-10-11 22:12 (UTC)From:sigh I really like grapefruit.
no subject
Date: 2020-10-12 00:05 (UTC)From:That's good to hear.
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>>*sigh* I really like grapefruit.
I don't think I've ever had grapefruit, and I think at this point I'm better off not knowing.
no subject
Date: 2020-10-12 00:12 (UTC)From:As a kid, my mother had grapefruit juice from concentrate, which I thought was horrible. As an adult, I kind of like grapefruit; I prefer good oranges, but e.g. navel oranges are often unreliably good (often dry and bland), while grapefruit is usually good.
no subject
Date: 2020-10-11 22:26 (UTC)From: